They have a base of operations in major cities of the Wasteland. In the Northern Wasteland it is located in the back of the "Second Chance" bar in Wellspring, and in the Eastern Wasteland it is found below Saul's Garage in Subway Town.
The protagonist first encounters them in the town of Wellspring after being told to find them by Antonin Kvasir. Granting his Ark 437a ID Drive with information vital to the Resistance, and later finding the Authority's lost research data in the Dead City, Raine quickly finds out that they may well be the best chance the world has for survival, as they are the only ones who care about the people of the Wasteland's future.
- Antonin Kvasir — Former Authority scientist
- Charon - Transporter
- Elizabeth Cadence — Mutant researcher
- Jack Portman — Munitions expert
- John Marshall — The movement's leader
- Mark Lassard — Computer expert
- Saul — Soldier, informant and engineer
- Nicholas Raine - Soldier
- Similar to the Authority, the Resistance appears to be testing on Mutants, as evident by an examined Slime Mutant in the Subway Town base.